Fig. 6 | Scientific Reports

Fig. 6

From: Molecular mechanisms and therapeutic targets in glioblastoma multiforme: network and single-cell analyses

Fig. 6

Drug sensitivity analysis of the high-risk and low-risk groups. (A) A glioma dataset from the Genomics of Drug Sensitivity of Cancer (GDSC) database was subjected to Pearson correlation analysis to examine the correlation between glioma and estimated half-maximal inhibitory concentration (IC50) values. The top 10 negatively correlated candidate compounds were identified. (B) Box plot of the IC50 values of the top 10 negatively correlated candidate compounds in the high-risk and low-risk groups. (C) The area under the curve (AUC) values of compounds from the Cancer Therapeutics Response Portal (CTRP) database were estimated for each patient with glioma. The significant correlation between glioma and AUC values was determined via Pearson correlation analysis on the basis of the following criteria: R > 0.4 and p < 0.05. (D) Box plot of the AUC values of negatively correlated compounds from the CTRP database in the high-risk and low-risk groups. (E) Table showing the names, IDs, targets, and pathways of the 10 drugs.

Back to article page