Fig. 2

Average hourly activity patterns do not differ between cKO and fl/fl mice, and both reduce their activity in LL. (A) Average hourly activity of fl/fl (n = 16) and cKO (n = 16) taken over 5 days in LD cycling. (B) Average hourly activity of fl/fl and cKO taken from one day at the end of DD conditions. (C) Average hourly activity of fl/fl and cKO taken from one day at the end of LL conditions. (D) Mean hourly distance travelled. LD represents average hourly activity over a 5-day period. DD and LL represents the final 48-hours of each condition. Both genotypes showed a reduction in activity in LL compared to LD (fl/fl *p = 0.0406, cKO *p = 0.0294) or DD (fl/fl *p = 0.0115, cKO *p = 0.0326).