Fig. 6 | Scientific Reports

Fig. 6

From: Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice

Fig. 6

Sex, and hepatic Npas2 expression, can influence central circadian gene expression in the forebrain. (A) A significant effect of genotype (**p = 0.0068), a significant interaction between time point and sex (*p = 0.0152), and a significant interaction between time point X genotype X sex (*p = 0.0145) were seen on Clock gene expression in the forebrain. (B) A significant effect of time point (**p = 0.0059), a significant effect of sex (**p = 0.0040), and a significant interaction between time point and sex (***p = 0.0008) were seen on Bmal1 gene expression in the forebrain. (C) A significant effect of time point (*p = 0.0105), a significant effect of sex (**p = 0.0187), and a significant interaction between time point and sex (*p = 0.0242) were seen on Rev-erbβ gene expression in the forebrain. n = 10 per genotype (n = 4 female, n = 6 male for cKO and fl/fl).

Back to article page