Fig. 2

Physical performance of young (Y) and middle-aged (M) mice. Total distance covered during 8 weeks of spontaneous wheel running (8-sWR) (n = 15–14) (A); total time of activity during 8-sWR (n = 15–14) (B); and mean velocity during 8-sWR (n = 14–14) (C) in Y and M mice. The data are presented as the means + SDs. Each data point in the dot plot represents one individual mouse. Two-sided p values are shown (Mann–Whitney U test). Statistically significant changes (p < 0.05) were plotted on the graphs.