Fig. 2 | Scientific Reports

Fig. 2

From: Rhodiola crenulata induces apoptosis in bone metastatic breast cancer cells via activation of caspase-9 and downregulation of MtMP activity

Fig. 2

The cytotoxic effects of R. crenulata were observed in 2D cultures of breast cancer cells (MM-231 and MCF-7) and 3D BM cultures of breast cancer cells in (A) MM-231 and (B) MCF-7 cells. The concentration dosages of 100, 200, 400, and 800 ppm of R. crenulata were used. Treatments were for 24 h. Alamar blue assay was used to evaluate the cell viability. The asterisk symbol (*) indicates a statistically significant difference between drug-treated and non-treated samples. *p < 0.05 **p < 0.01 ***p < 0.001.

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