Fig. 7

The profiles of total phosphate (P) in plasma and ion phosphate in intracellular space predicted by Model IC and Model IC&F during the weekly cycle of three hemodialysis (HD) sessions for different clearances between extracellular and intracellular compartments. Shown are total phosphate in plasma (panel a) and ion phosphate in intracellular compartment (panel b) predicted by Model IC for standard set of parameters, Table 2, (continuous line), intercompartment clearance, \(K_{P\_ei}\), reduced by 50% (dotted line) and increased by 50% (hatched line). Panels c and d present the predictions for similar modifications of standard intercompartment clearance, \(K_{P\_ei}\), for Model IC&F. Other model parameters (Table 1) were the same for all the three simulations for each of the models.