Fig. 5

Transcriptome alterations of HepG2 cells were uncovered by high-throughput sequencing. (A) Scatter plot of repeat correlation check. The horizontal and vertical axes are the log₁₀(TPM) values of the two samples respectively. The more similar the samples, the closer the similarity index is to 1, and most of the points in the figure will be clustered near the diagonal. (B) MA map of comparison group expression difference. The horizontal axis is the average log₂(TPM) of the two groups of samples, that is, (log₂ (A) + log₂ (B))/2, and the vertical axis is log₂(Foldchange), that is, the log₂(B/A) value. The red, green, and black spots showed up-regulated, down-regulated, and no difference genes, respectively. (C) GO enrichment analysis. (D) KEGG enrichment analysis of the top 30 DEGs. (E) The FOXO signal pathway.