Fig. 4 | Scientific Reports

Fig. 4

From: Complete preclinical evaluation of the novel antibody mimetic Nanofitin-IRDye800CW for diverse non-invasive diagnostic applications in the management of HER-2 positive tumors

Fig. 4

Ex vivo analysis of NF-800 efficacy in OE-19 orthotopic tumor bearing mice 6 h after administration. (a), Ex vivo photograph and fluorescence intensity image of OE-19 orthotopic tumor model after i.v. administration of NF-800 (Asterisks indicate the tumor in both images). (b), Ex vivo comparison analysis of NF-800 biodistribution in BT-474 xenograft and OE-19 orthotopic tumor bearing mice. (c), Comparison of the ex vivo efficacy of NF-800 (10 nmol/mouse) vs Tz-800 (2.5 mg/kg) in OE-19 orthotopic tumor model. Data are expressed as tumor-to-muscle ratio (Mean ± SD). For each group at least n = 5.

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