Fig. 4
From: Anticancer drugs targeting topoisomerase II for antifungal treatment
S. cerevisiae ATCC 9763 cells incubated for 1 h (A) or 3 h (B) with idarubicin 2 µg mL− 1, 4 µg mL− 1 and 100 µM H2O2 after staining with Hoechst 33342 and Mitotracker green. (A) White arrows indicate aggregated mitochondria, selected cells with fragmented genetic material undergoing the apoptotic process is marked by yellow arrows Under magnification in square frames, the fusion of mitochondrial DNA with nuclear DNA is visible. Scale bars correspond to 5 μm. Controls are indicated as Ctrl.
