Table 4 Antifungal activity of selected compounds against fluconazole-resistant C. glabrata clinical strains in comparison with C. glabrata DSM 11226. * > means no activity at the concentration mentioned. In this assay, the MIC value of fluconazole was recorded as positive control. The experiments were performed at least in five replicates.
From: Anticancer drugs targeting topoisomerase II for antifungal treatment
Strains | MIC* µg mL− 1 | ||||||
|---|---|---|---|---|---|---|---|
Idarubicin | Epirubicin | Daunorubicin | Mitoxantrone | Pixantrone | Bisantrene | Flu | |
DSM 11226 | 1 | 32 | 64 | 32 | 32 | > 64 | 32 |
CZD373 | 8 | > 64 | > 64 | 32 | 32 | > 64 | > 64 |
CZD377 | 32 | > 64 | > 64 | 32 | 32 | > 64 | > 64 |
CZD513 | 16 | > 64 | > 64 | 32 | 32 | > 64 | > 64 |
Gd 10 | 32 | > 64 | > 64 | 32 | 32 | > 64 | > 64 |
