Fig. 6 | Scientific Reports

Fig. 6

From: Molecular dynamics, docking and quantum calculations reveal conformational changes influenced by CYP271A amino acid mutations related to cerebrotendinous xanthomatosis

Fig. 6

Structural changes observed in substrate access channels in the WT and mutants identified by Caver 3.0. (A) The initial model of WT CYP27A1 shows 2 channels, I and II. From this point on, the channels were also monitored in the MPCC of (B) WT, (C) M1, (D) M2, (E) M3, (F) M4, (G) M5, (H) M6, and (I) M7.

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