Fig. 1 | Scientific Reports

Fig. 1

From: Network pharmacology and experimental validation reveal dexmedetomidine’s protective mechanisms against acute liver injury in mice

Fig. 1

Dexmedetomidine alleviates oxidative stress and inflammation in mouse liver. (A) H&E staining illustrating histopathological alterations; scale bar = 50 μm. (B,C) Quantification of ALT and AST in mouse serum. (D–G) Quantification of IL-6, IL-1β, IL-8, and TNF-α in mouse serum. (H) DHE fluorescence staining revealing oxidative stress in liver tissues. (I) Quantitative DHE analysis. Data are shown as mean ± SD (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared to the ALI group. Groups: Con (control), ALI (acute liver injury), DEX (dexmedetomidine), SIL (silymarin). NS denotes nonsignificant differences.

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