Fig. 1 | Scientific Reports

Fig. 1

From: Preclinical assessment of a ganglioside-targeted therapy for Parkinson’s disease with the first-in-class adaptive peptide AmyP53

Fig. 1

Interaction of wild-type α-synuclein proteins and AmyP53 with GT1b ganglioside monolayers. Monolayers of ganglioside GT1b were prepared at the air-interface at an initial surface pressure of 17.5 mN/m. After equilibrium, wild-type (wt) or or AmyP53 was added in the aqueous subphase underneath the monolayer at the indicated concentrations. Surface pressure measurements were recorded in real-time until reaching a plateau value, typically after 1 h of incubation. The values correspond to the maximal surface pressure increase measured when the system has reached a state of equilibrium. The data are expressed as mean ± SD of three independent experiments. A logistic fit was applied to each curve.

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