Fig. 9 | Scientific Reports

Fig. 9

From: Preclinical assessment of a ganglioside-targeted therapy for Parkinson’s disease with the first-in-class adaptive peptide AmyP53

Fig. 9

Interaction of AmyP53 with gangliosides extracted from the brain of rats and rabbits and from human red blood cells (RBC). Gangliosides were spread as stable monolayers at the air-water surface. AmyP53 (10 µM) was injected underneath these monolayers and the interaction was followed by measurements of the surface pressure increase (blue histograms). The grey histograms represent a control experiment without AmyP53. In all cases the data are expressed as mean ± SD of three independent experiments (plateau values reached after 60 min of incubation). The statistical significance of the data was assessed using Student’s t-test (**, p < 0.01; ***, p < 0.001).

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