Table 3 Physicochemical characteristics and metabolic stability of AmyP53 in vitro.
Matrix | AmyP53 t1/2 | Propantheline t1/2 | AmyP53 bound to plasma protein % | Propranolol bound to plasma protein % |
|---|---|---|---|---|
Rat plasma | 787 min | 227 min | 93.4 ± 0.6 | 89.8 ±0.1 |
Rabbit plasma | 601 min | 17 min | 81.7 ±0.8 | 74.8 ±1.1 |
Mini-pig plasma | 364 min | 179 min | 81.4 ±0.8 | 85.2 ±0.9 |
Dog plasma | 83 min | 104 min | 84.6 ±4.3 | 86.5 ±1.0 |
