Fig. 6

A. Dox and doxorubizen both act as intercalators within the same DNA base pairs. B. Dox, DNA minor groove binding agent; doxorubizen, DNA major groove binding agent. C. Doxorubizen acts as Topo II inhibitor, detailed interactions (hydrogen bond: black; p-p stacking: cyan; aromatic-H bond: violet; salt bridge: pink). D. Doxorubizen (space-filling model) acts as intercalator showing between DNA base pairs.