Table 2 Distribution of NR3C1; Bcl1 rs41423247 and rs6198 genotypes and alleles in obese children versus controls.

From: Genetic association between glucocorticoid receptor gene Bcl1 rs41423247 and rs6198 polymorphisms and risk of obesity in Egyptian children

 

Group with obesity (n = 60) N (%)

Control group (n = 40) N (%)

Relative risk of obesity

OR (95%CI)

P value

NR3C1; Bcl1 rs41423247

Genotypes

CC

15 (25.0%)

20 (50.0%)

Reference

-

CG

31 (51.7%)

16 (40.0%)

2.583 (1.049–6.361)

0.039*

GG

14 (23.3%)

4 (10.0%)

4.666 (1.275–17.077)

0.019*

CG + GG

45 (75.0%)

20 (50.0%)

3.00 (1.279–7.031)

0.011*

Alleles

C

61 (50.8%)

56 (70.0%)

2.256 (1.241–4.101)

0.007*

G

59 (49.2%)

24 (30.0%)

NR3C1 rs6198

Genotypes

AA

27 (45.0%)

19 (47.5%)

Reference

-

AG

24(40.0%)

17(42.5%)

0.993 (0.422–2.335)

0.988

GG

9(15.0%)

4(10.0%)

1.583 (0.424–5.903)

0.493

AG + GG

33(55.0%)

21(52.5%)

1.105 (0.495–2.466)

0.805

Alleles

A

78(65.0%)

55(68.8%)

1.184 (0.647–2.166)

0.582

G

42(35.0%)

25(31.2%)

  1. A: adenine, C: cytosine, G: Guanine, Logistic regression analysis test was used, Reference genotype and allele according to NCBI, CI: confidence interval, OR: odds ratio, OR < 1 is considered protective and OR > 1 is considered risky, *significant: P value < 0.05.
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