Fig. 3

Open field total activity (a, b) and center ambulation (c, d) measured in photobeam interruptions. (a) Total ambulation over 5 biweekly tests. (b) Main effect for total ambulation. All irradiated groups had reduced ambulation compared with Sham. The CV and FLASH groups did not differ for total ambulation. (c) Center ambulation over 5 biweekly tests. (d) Main effect for center ambulation. All irradiated groups had reduced center ambulation compared with Sham. Center ambulation for CV and FLASH groups was not significantly different. No interactions were significant. Open field activity was analyed by Dunnett’s and an irradiation × week (repeated) ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001. Sham = 21, FLASH-95 = 18, FLASH-60 = 16, and CV = 21.