Fig. 4 | Scientific Reports

Fig. 4

From: Intratracheal Candida administration induced lung dysbiosis, activated neutrophils, and worsened lung hemorrhage in pristane-induced lupus mice

Fig. 4

Flow cytometry analysis of the spleens from control, pristane injection, Candida administration (Candida), and pristane plus Candida (Pris + Can) as indicated by the abundance of plasma cells (CD138 and B220 positive) (A), naïve Th cells (CD62L positive with CD44 negative) (B), total control memory T cells (CD3, CD44, and CD62L positive) (C), total Th cell (CD4 positive CD8 negative) (D), central memory Th cell (CD3, CD4, and CD62L positive) (E), effective memory Th cells (CD3 and CD4 positive with CD62L negative) (F), inducible T cell costimulatory (CD4 and ICOS positive) (G), central memory CD8 T cells (CD8 and CD62L positive) (H), adaptive B cells (GL7 and B220 positive) (I), IgM-producing B cell (IgM and B220 positive) (J), dendritic cells (CD80 and CD11c positive) (K), and activated dendritic cells (ICOS and CD11c positive) (L) are demonstrated (n = 5/ group). Lung tissue cytokines (TNF-a, IL-6, and IL-10) (M–O) are also demonstrated (n = 5/ group).

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