Fig. 2
From: Ultrasound guided blood brain barrier opening using a diagnostic probe in a whole brain model
B-mode images showing the MB distribution before (a), during (b,c), and after (d) the US-mediated BBB opening. The white line represents the base of support for the brain. The therapeutic US beam is targeted towards the left hemisphere, as indicated by the rectangles, while the grey diagnostic US beams intersect both hemispheres. The yellow color in the first, third, and fourth panels indicates that the TUS beam is off, whereas the red color in the second row indicates that the TUS beam is on. (a) B-mode acquisition before the start of US treatment, showing the MB distribution within the brain (time t = 0″). (b: t = 80″) and (c: t = 168″) Effects of the interfering TUS beam on MB distribution during and at the end of the US treatment, respectively. (d: t = 180″) B-mode acquisition following the conclusion of the US treatment.
