Fig. 4 | Scientific Reports

Fig. 4

From: Exome sequencing reveals low-frequency and rare variant contributions to multiple sclerosis susceptibility in Turkish families

Fig. 4

Enrichment analysis results of (A) incomplete dominant genes in gene-based segregation across HPO, Reactome, WikiPathways, and KEGG Pathway databases. Q-value (false discovery rate [FDR]) cutoff is 0.01 for significance. The gradient color indicates Q-values, where darker red represents higher statistical significance (Q = 0). Node size corresponds to gene set size. Larger nodes represent larger gene sets and edge thickness indicates shared genes between pathways. (B) Protein-protein interaction network of genes from segregation filter enriching for ECM organization and their clustering using k-means clustering within STRING. The edge thickness represents the significance of the associations, while the dotted edges indicate gene interactions between distinct clusters.

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