Table 1 Effect of MEM on testicular MDA, NOx, SOD, GSH and CAT levels.

From: Memantine abrogates testicular dysfunction induced by risperidone in rats with a potential role of ERK1/2-Nrf2-caspase-3 signaling pathway

Group

MDA

(mmol/g tissue)

NOx

(nmol/g tissue)

SOD

(U/g tissue)

GSH

(mg/g tissue)

CAT

(U/g tissue)

Control

13.4 ± 0.67

15.50 ± 0.90

40.40 ± 0.66

112.8 ± 2.15

139.5 ± 4.28

MEM-5

13.0 ± 1.02

14.4 ± 1.05

40.53 ± 0.38

111.5 ± 2.40

137.30 ± 4.32

MEM-10

11.77 ± 0.54

16.94 ± 1.38

40.17 ± 0.57

112.8 ± 2.94

140.20 ± 5.93

RIS

38.73 ± 2.99a

40.2 ± 2.35a

19.94 ± 0.70a

68.83 ± 2.61 a

87.67 ± 2.84 a

RIS + MEM-5

30.36 ± 2.31b

32.85 ± 0.84b

23.60 ± 1.32b

79.50 ± 3.08

96.67 ± 3.35

RIS + MEM-10

20.84 ± 1.47bc

22.91 ± 1.48bc

31.13 ± 0.47bc

92.83 ± 3.12bc

117.50 ± 4.07 bc

  1. Results represent the mean ± SEM (n = 6). Significance is at p < 0.05. asignificant difference relative to control group; bsignificance difference with respect to RIS group; csignificance difference against RIS + MEM-5 group.
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