Fig. 3

Three-dimensional structure of ApoE fusion protein. Complement repeats (CR) in low-density lipoprotein receptor (LDLR) protein have a high-affinity calcium-binding site allowing them to fold properly. This figure shows ApoE amino acid residues 130–149 interacting with CR17 of LDLR-related protein 1 bound to calcium ion (PDB id 2KNY).