Table 1 Common drug candidates identified across three drug-Repurposing platforms.

From: A feasibility of computational drug screening for Fuchs endothelial corneal dystrophy

Drug candidates

Description

L1000FWD

(Similarity score)†

L1000CDS2

(Overlap)#

SigCom LINCS

(z sum)‡

Cercosporin

Protein kinase C inhibitor

−0.0698

0.074

−19.27

LDN193189

Selective bone morphogenetic protein signaling inhibitor

−0.0999

0.101

−19.83

Menadione

Phosphatase inhibitor

−0.0762

0.083

−19.10

BRD-K68313733

N/A

−0.1257

0.086

−22.66

BRD-A40431293

N/A

−0.0816

0.078

−19.39

  1. † Similarity score calculation: ratio of overlapping up/downregulated genes to effective input gene count. # Search score determination: proportion of shared differentially expressed genes (DEGs) between input and database, normalized by effective input size. ‡ Z-sum calculation: aggregate of z-scores from up- and downregulated gene sets, used for signature prioritization.
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