Fig. 1 | Scientific Reports

Fig. 1

From: Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex

Fig. 1

Environmental enrichment effectively reduced anxiety-like behaviors in mice with neuropathic pain (A) Schematic of the experimental timeline (Created with bioRender.com). (B) Body weight monitoring during the experiment. (C) Paw withdrawal threshold to mechanical stimulation in the plantar test. (D) Paw withdrawal latency to heat stimulation in the plantar test. (E) Trajectories of mice in the OFT. (F) Total distance traveled throughout the area in the OFT. (G) Time spent in the central area of the OFT. (H) Trajectories of mice in the EPMT. (I) Total distance in the EPMT. (J) Time spent in open arms in the EPMT. (K) Schematic of novelty-suppressed feeding test. (L) Latency to initiate feeding in the NSFT. (M) Food consumption in the NSFT. All data represent the mean ± SEM (n = 12 mice per group). *p < 0.05, **p < 0.01, ***p < 0.001 versus the sham group; #p < 0.05 versus SNI group.

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