Table 1 Summary of cost and runtime for association analysis pipeline using RAPpoet. Note that the cost and runtime of each step is a function of EC2 instance type, job priority, etc. See supplementary material and tables for more detailed costings and runtime. Note that fine mapping was run locally as PolyFun was not available on the UKB RAP.

From: Optimizing UK biobank cloud-based research analysis platform to fine-map coronary artery disease loci in whole genome sequencing data

Step

Chromosome 9

Chromosome 21

Cost (£)

Runtime (Min)

Cost (£)

Runtime (Min)

Quality Control Step One

176.50

1103

97.05

323

Quality Control Step Two

33.33

855

5.41

216

sLR

0.078

15

0.033

6

REGENIE

2.75

91

0.23

31

VariantSpark

179.31

796

56.14

499