Fig. 1
From: Development and evaluation of curcumin nano-niosomes for glioma-targeted therapy
Diagram of the delivery of TF-Cur-Nio across the BBB. TF ligands on the Nio surface bind to TFR overexpressed on BBB endothelial cells and glioma cells, triggering receptor-mediated endocytosis and facilitating drug transport into the brain. The nonionic surfactant components of the Nios can help circumvent P-gp efflux, thereby enhancing curcumin accumulation within tumor tissues.
