Fig. 4

Remimazolam attenuated LPS-induced cognitive dysfunction and anxiety-like behaviors. (A,B) The Morris Water Maze (MWM) test results showed that (A) treatment with remimazolam shortened the escape latency time of rats, and (B) markedly increased the time spent in the target quadrant and the platform crossover, suggesting an ameliorative effect of remimazolam on LPS-induced cognitive impairment. (C) Representative swimming traces of rats during probe trials of MWM test. (D) An increase in total distance, frequency of rearing, time spent in the central zone and frequency of crossing in the Open Field Test (OFT) indicated a positive effect of remimazolam on LPS-induced anxiety-like behaviors. (E) The representative tracking images of rats in the OFT. Results are shown as means ± SEM (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001.