Table 8 Mendelian randomization analysis results of rheumatoid arthritis on bone necrosis.

From: Exploring the association between systemic lupus erythematosus and osteonecrosis by Mendelian randomization analysis

Method

Estimate

Std Error

OR

95% CI

P-value

Simple median

− 0.233

0.221

0.792

0.514

1.220

0.291

Weighted median

− 0.232

0.201

0.793

0.535

1.176

0.248

Penalized weighted median

− 0.229

0.199

0.795

0.538

1.176

0.250

IVW

− 0.288

0.141

0.750

0.569

0.988

0.041

Penalized IVW

− 0.288

0.141

0.750

0.569

0.988

0.041

Robust IVW

− 0.215

0.180

0.807

0.567

1.148

0.232

Penalized robust IVW

− 0.215

0.180

0.807

0.567

1.148

0.232

MR-Egger

0.254

0.278

1.289

0.748

2.223

0.360

Penalized MR-Egger

0.254

0.278

1.289

0.748

2.223

0.360

Robust MR-Egger

0.212

0.415

1.236

0.548

2.790

0.609

Penalized robust MR-Egger

0.212

0.415

1.236

0.548

2.790

0.609

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