Table 9 Information on the 10 most significant gene sets in MAGMA gene set enrichment analysis.

From: Exploring the association between systemic lupus erythematosus and osteonecrosis by Mendelian randomization analysis

Gene Set

N genes

Beta

Beta STD

SE

P

Pbon

REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS

2

3.9315

0.12194

0.53967

3.6004e − 13

3.82866536e − 09

REACTOME_DEFECTIVE_B4GALT7_CAUSES_EDS_PROGEROID_TYPE

2

3.9315

0.12194

0.53967

3.6004e − 13

3.82866536e − 09

REACTOME_DEFECTIVE_EXT2_CAUSES_EXOSTOSES_2

2

3.9315

0.12194

0.53967

3.6004e − 13

3.82866536e − 09

REACTOME_DISEASES_ASSOCIATED_WITH_GLYCOSAMINOGLYCAN_METABOLISM

2

3.9315

0.12194

0.53967

3.6004e − 13

3.82866536e − 09

REACTOME_HS_GAG_BIOSYNTHESIS

2

3.9315

0.12194

0.53967

3.6004e − 13

3.82866536e − 09

REACTOME_ATTACHMENT_AND_ENTRY

3

3.8564

0.14646

0.53686

7.3073e − 13

7.76692917e − 09

REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

4

3.719

0.16305

0.5249

1.4328e − 12

1.52277984e − 08

REACTOME_HS_GAG_DEGRADATION

4

3.719

0.16305

0.5249

1.4328e − 12

1.52277984e − 08

PID_SYNDECAN_3_PATHWAY

2

3.7129

0.11516

0.52961

2.3771e − 12

2.52590646e − 08

GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS

2

2.7264

0.084561

0.42274

9.3065e − 11

9.88815625e − 07