Fig. 4
From: Magnetic hyperthermia therapy enhances the chemoradiosensitivity of glioblastoma
MIONP concentration and AMF conditions determine temperature of intracranial heating in mice. A–D Healthy mice (n = 3) were exposed to an external AMF (383.5 kHz, 8.28kA/m) and intracranial temperature measurements were recorded immediately post-delivery of MIONPs by convection-enhanced delivery (CED) for a total of 15 min (AMF ON for 10 min and AMF OFF for 5 min). Mice underwent CED of MIONPs with (A) 80 mg/ml at 10ul, (B) 80 mg/ml at 8ul, (C) 60 mg/ml at 8ul and (D) 40 mg/ml at 8ul. (E) To replicate the therapeutic MHT + CRT scheme, temperature measurements were performed 24 h and 48 h post-CED (80 mg/ml, 8ul, 0.5ul/min) for a total of 15 min (AMF ON for 10 min and AMF OFF for 5 min) on the same mouse (n = 1). (F) Temperature measurement results showing repeated MIONPs heating 24 h and 48 h post CED in the same mouse brain.
