Fig. 8 | Scientific Reports

Fig. 8

From: Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer’s disease

Fig. 8

The change of speed and theta oscillations in hippocampal CA1. (A) Representative power spectrogram of theta frequency from WT and 5xFAD mice at rest and move. (B) Representative speed plot and corresponding filtered theta component of the signal from WT and 5xFAD mice in OFT. (C) The average speed of WT and 5xFAD mice. (D) The power of theta oscillations at rest and during locomotor activity. (E) The correlation between speed and corresponding theta power in hippocampal CA1 during locomotor activity (WT: Y = 1.417e-009*X + 1.371e-008; p < 0.05; 5xFAD: Y = 9.183e-012*X + 6.080e-009; p = 0.248; linear regression F-test). The bars indicate the means ± SEM; n = 5 per group; *p < 0.05 (Unpaired t test).

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