Fig. 1
From: Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations
SF3B1 mutant MDS cells show a distinctive spliceosome landscape. (A) Unsupervised hierarchical clustering of significant AS events in SF3B1-mutant and SF3B1-WT MDS samples. AS events, PSI normalized values (Z-score) across samples are represented in rows. As events were considered significant if pass the predefined threshold (FDR < 0.05 and LogFC > −/ + 1.5). (B) Volcano plots showing the significance and effect size of identified AS events in SF3B1-mutant and SF3B1-WT MDS samples. Colors represent the type of AS event. (A3SS) alternative 3′ splice site usage, (SE) skipped exons, (A5SS) alternative 5′ splice site usage, (AFE) alternative first exons, (IR) intron retention, (ALE) alternative last exons, (NS) not significant.
