Table 2 Comparison of IFN-γ and cytotoxic granule molecule secreting T cell responses between unvaccinated adults and children with and without SARS-CoV-2 infection.

From: Functional T cell response to COVID-19 vaccination with or without natural infection with SARS-CoV-2 in adults and children

Spot-forming units per

Infected (n = 34)

Uninfected (n = 20)

million PBMC

Adults (n = 13)

Children (n = 21)

p-value

Adults

(n = 10)

Children (n = 10)

p-value

IFN-γ

 PepMix-1

55.5 ± 2.29

95.5 ± 2.15

0.060

20.6 ± 3.96

72.8 ± 5.15

0.078

 PepMix-2

53.4 ± 2.09

86.1 ± 2.09

0.075

27.6 ± 3.04

72.6 ± 4.06

0.105

Perforin

 PepMix-1

49.2 ± 2.72

69.0 ± 2.39

0.310

30.1 ± 2.63

35.2 ± 2.72

0.728

 PepMix-2

52.0 ± 2.74

70.3 ± 2.32

0.352

30.0 ± 2.71

36.6 ± 2.67

0.656

Granzyme B

 PepMix-1

21.9 ± 3.51

64.4 ± 2.25

0.005

10.1 ± 3.24

41.2 ± 1.94

0.004

 PepMix-2

19.8 ± 3.40

52.0 ± 2.02

0.006

13.0 ± 2.83

41.7 ± 1.78

0.006

  1. All the data were log-transformed and reported as geometric mean (back-transformed) with standard deviation. An independent t-test was conducted to calculate the p-value.
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