Table 2 Results of the evolutionary model fitted for the evolutionary rates of SCC, SCC_RY, SCC_SW, SCC_KM, PR_K1, S1_K1, CpG, UUG. Each rate metric was regressed against time with RRphylo function search.trend to test for Temporal trends in the metric values, either computing the rate regression of the metric against time as is (p.real) and ranking the real data slope against a family of 100 randomly generated slopes obtained simulating the brownian motion model of evolution. In addition, we fitted the brownian motion model of evolution by either ignoring (BM) or admitting (BMT) the existence of a trend (term ‘trend’) in the rate metric over time. BM is compared to BMT by means of a likelihood ratio test, whose P.value is reported in the table (LRT_p).

From: Strong evidence for the evolution of decreasing compositional heterogeneity in SARS-CoV-2 genomes during the pandemic

 

search.trend

Brownian motion with and without trend

trend suggested by both search.trend and BMT

GENOME TRAIT

slope

p.real

p.random

AIC.BM

AIC.BMT

trend

LRT_p

SCC

5.81

0.94

0.01

−12997.511

−13101.695

−545.243

<< 0.001

decrease

SCC_RY

552.85

0.00

1.00

−14177.235

−14470.451

−684.446

<< 0.001

 

SCC_SW

−530.06

0.00

0.01

−14772.989

−14790.022

−317.441

<< 0.001

decrease

SCC_KM

185.70

0.01

0.27

−14006.345

−14128.078

−561.388

<< 0.001

 

PR_K1

2153.57

0.00

1.00

−11850.513

−11933.035

1000

<< 0.001

increase

S1_K1

1056.07

0.00

1.00

−13319.047

−13423.167

−548.197

<< 0.001

 

CpG

653.81

0.00

1.00

6014.193

5869.966

1000

<< 0.001

increase

UUG

354.39

0.00

1.00

4929.028

4891.79

−407.604

<< 0.001