Fig. 5

Analysis of cancer-associated DNA variants in Grenfell Fire firefighters. (a) Workflow used in the identification of somatic variants in the cfDNA of LFB firefighters in the GFS. Three different filtering criteria were used, followed by a multiscore analysis of the filtered variants. We used five independent scores (multiscore analysis) to classify these variants as pathogenic (see Methods section). (b) List of individual cfDNA variants present in the GFS cohort. HGVSP, Human Genome Variation Society amino acid ID; Ref, reference allele; Alt, alternate allele. “Type” indicates whether the variant corresponds to a transition (Ti) or a transversion (Tv) event. (c) Exposure categories within the cohort of firefighters analysed by NGS (n = 261) and for the firefighters in whom pathogenic variants were detected (n = 11). The numbers inside the boxes indicate the number of observations per category.