Fig. 7
From: Mapping the anatomical and transcriptional landscape of early human fetal ovary development
Identifying novel meiosis candidate genes. (a) Gene enrichment analysis (Metascape) of differentially expressed genes (log2FC > 2, p.adj < 0.05) at 15/16wpc, confirming an enrichment of genes related to meiosis and germ cell competence. (b) Venn diagram overlapping the PanelApp geneset; differentially expressed PanelApp genes in the ovary v testis (log2FC > 2, p.adj < 0.05); and meiosis-annotated genes on enrichment analysis of genes differentially expressed in the 15/16wpc ovary v 15/16wpc testis and 15/16wpc ovary v ovary CS22/23. (c) Genes differentially expressed in the 15/16wpc ovary v 15/16wpc testis and 15/16wpc ovary v ovary CS22/23 which were not annotated on enrichment analysis as meiosis genes were identified (n = 622) and overlapped with markers of the oogonia cluster (n = 33) to extract potentially novel candidate meiosis genes. (d) Dot plot showing expression of 33 potentially novel meiosis candidate genes across cell clusters.
