Fig. 5 | Scientific Reports

Fig. 5

From: Differential biomarker expression of blood and lymphatic vasculature in multi-organ-chips

Fig. 5The alternative text for this image may have been generated using AI.

Flow upregulates LEC-specific gene expression. mRNA expression of BECs and LECs cultured without flow and 7 days with flow showing expression of (A) LEC-specific genes CCL21, PROX1 and TFF3 in LECs, (B) EC-specific genes SOX18 and COUPTF2, and (C) adherens and tight junction genes VE-cadherin, CLDN-5, ZO-1 in BECs and LECs. The data represent mean ± SEM; n = 3; ns = not significant; *p < 0.05; paired t-test. Symbols in bar graph represent different experimental repeats with different donors (● repeat 1, ■ repeat 2, ▲ repeat 3).

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