Fig. 4 | Scientific Reports

Fig. 4

From: Rapid formulation of a genetically diverse phage cocktail targeting uropathogenic Escherichia coli infections using the UTI89 model

Fig. 4

Phages SR02 and SR04 are genetically divergent and are clustered into different genera. (a) A whole genome-based phylogenetic tree of phages SR02 (orange) and SR04 (blue) was constructed using the Genome-BLAST Distance Phylogeny (GBDP) method and VICTOR web service with 100 bootstraps. Representative phage species are selected from the search of SR02 and SR04 against the NCBI and ICTV databases. Numbers at branches and branch colors represent the percentage of bootstrap values and phage clusters, respectively. The phage genus is indicated at the branch of each phage cluster. (b) VIRIDIC heatmap illustrating the intergenomic similarities of SR02 (orange) and SR04 (blue) with their closely related phages. The numbers represent the intergenomic similarity values for each genome pair. (c) Comparative genomic analysis of SR02 (orange) and SR04 (blue) with their closest related phages (phiEco32 and vB_EcoP_F). Green arrows represent the directions and locations of coding sequences. Gray-shaded lines reflect the degree of homology between them.

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