Fig. 3 | Scientific Reports

Fig. 3

From: Oral andrographolide loaded lipid nanocarriers alleviate stress behaviors and hippocampal damage in TNF alpha induced neuroinflammatory mice

Fig. 3

Physical and biochemical profiles of body and organ weights, serum and hippocampal biomarkers in male mice with TNF-alpha-induced inflammation. (A) Experimental design in the animal study, (B) starting body weight, (C) final body weight, (D) percentage of daily weight gain change, (E) relative adrenal gland weight, (F) spleen weight, (G) thymus weight, (H) serum corticosterone, (I) alanine transaminase (ALT) and (J) aspartate aminotransferase (AST) levels, (K) hippocampal interleukin (IL)-6, (L) tumor necrosis factor (TNF)-alpha and (M) malondialdehyde (MDA) levels. The data are presented as mean ± SEM (n = 5–9 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001 versus control, †P < 0.05,††P < 0.01, †††P < 0.001 versus vehicle, and #P < 0.05, ##P < 0.01,###P < 0.001 versus Andro. Andro, Andrographolide; AndroNLCs, Andrographolide-loaded nanostructured lipid carriers; DEXA, dexamethasone; VLX, venlafaxine.

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