Fig. 6 | Scientific Reports

Fig. 6

From: Oral andrographolide loaded lipid nanocarriers alleviate stress behaviors and hippocampal damage in TNF alpha induced neuroinflammatory mice

Fig. 6

The summary of the study shows the composition, which includes andrographolide (Andro), sesame oil, and glycerol monostearate (GMS). This representation demonstrates the effectiveness of Andrographolide-loaded nanostructured lipid carriers (AndroNLCs), showing low cytotoxicity and significant anti-inflammatory effects in lipopolysaccharide (LPS)-pretreated SH-SY5Y neuroblastoma cell cultures, with reduced levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Additionally, AndroNLCs effectively alleviated anxiety, depression, and compensatory responses to TNF-alpha challenge in male C57BL/6 mice. This was demonstrated by decreased targeted organ weights, reduced corticosterone, lower hippocampal IL-6, TNF-alpha, oxidative stress levels, and improved hippocampal morphology and pyknosis with increased cell survival, suggesting potential for mitigating neuroinflammation-induced behavioral abnormalities.

Back to article page