Fig. 7
From: Celastrol loaded nanocomplex for painless tumor therapy via YAP inhibition
Behavioural test and analysis of analgesic mechanisms. The curves of the mechanical withdrawal threshold (a) and thermal withdrawal latency (b) throughout the treatment period. Measurements were taken 8 h post-treatment after each treatment. ELISA assays of cytokine levels: (c) IL-6, (d) TNF-α. (e) Immunofluorescent staining of VEGF, VEGFR1 and PGP9.5 in the tumor after treatment. (f) Western blot assay of YAP, VEGF, and VEGFR1 proteins in tumor following the completion of treatment. (*p < 0.05, **p < 0.01 and ***p < 0.001).
