Fig. 5 | Scientific Reports

Fig. 5

From: Root cause analysis investigation of visible particulates in therapeutic protein drug products using morphologically directed Raman spectroscopy

Fig. 5

Composite morphological score using principal component analysis (PCA) of morphological features (Table S1) for VP standards, NIST candidate reference materials, and stressed TPs. (A) PCA with all features (size, shape, transparency). (B) PCA with only shape and transparency features. Each point represents one particle. Results show tight clustering for PS microspheres and SU-8 particles, compared to dispersion throughout the plot for ETFE particles and stressed TP VPs.

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