Table 3 The univariate analysis for the OS and PFS.

From: The efficacy and safety of thymosin alpha-1 combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a retrospective study

 

OS

PFS

χ2

P value

χ2

P value

Gender (female vs. male)

0.244

0.621

0.046

0.831

Age, year (≤ 40 vs. > 40)

3.331

0.068

0.516

0.472

ECOG-PS, score (0 vs. 1)

0.010

0.921

0.175

0.676

Child–pugh (A vs. B)

2.266

0.132

2.512

0.113

BCLC (B vs. C)

6.886

0.009

2.206

0.137

Therapeutic regimen (control vs. experimental)

5.116

0.024

6.362

0.012

Alcohol use (yes vs. no)

0.689

0.406

0.633

0.426

Concomitant disease (yes vs. no)

2.357

0.502

1.477

0.688

HBsAg (yes vs. no)

0.194

0.659

0.136

0.712

HBV-DNA (negative vs. positive)

0.161

0.688

0.469

0.493

Tumor differentiation(poorly vs. well and moderately)

8.245

0.010

3.664

0.056

Extrahepatic metastasis (yes vs. no)

6.648

0.010

0.003

0.960

Esophageal varices (yes vs. no)

1.233

0.267

1.629

0.202

Portal hypertension (yes vs. no)

0.075

0.784

0.001

0.970

Macrovascular invasion (yes vs. no)

0.363

0.547

1.123

0.289

ALT, U/L (≤ 40 vs. >)

0.138

0.710

0.001

0.977

TB, µmol/L (≤ 20 vs. > 22)

8.898

0.003

1.987

0.159

PT, second (≤ 16 vs. > 16)

7.515

0.006

9.216

0.002

INR (≤ 1.2 vs. > 1.2)

0.953

0.329

0.071

0.790

PIVKA-II, mAU/mL (≤ 40 vs. > 40)

0.453

0.501

2.717

0.099

AFP, ng/ml (≤ 200 vs. > 200)

10.878

0.001

6.077

0.014

  1. OS: Overall survival, PFS: progression free survival. Significant values are in bold.