Fig. 4 | Scientific Reports

Fig. 4

From: Transmissibility of a new Plasmodium falciparum 3D7 bank for use in malaria volunteer infection studies evaluating transmission blocking interventions

Fig. 4

Simulated piperaquine plasma concentration–time profiles relative to study day (upper horizontal axes) and time after first dose (lower horizontal axes). An additional dose of 960 mg administered 9 days (a) post-initial dosing was predicted to have ≥ 95% probability of sufficient piperaquine exposure for up to 32 days post-inoculation, thereby preventing asexual parasitemia recrudescence during mosquito transmission assessment. The piperaquine plasma concentration time profile for administration of 960 mg of piperaquine 6 days post initial dosing is also shown (b). The solid line and the shaded area represent the median concentration and 95% prediction interval, respectively. The dashed line represents the piperaquine minimum inhibitory concentration (MIC)33.

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