Fig. 8

Correlation between key functional differential genera and pro- and anti-inflammatory cytokines and chemokines. Heatmap illustrating Spearman’s correlation coefficients between specific genera of fecal microbiota and pro- and anti-inflammatory cytokines and chemokines in adolescents with MDD. Statistical significance was assessed using Spearman’s correlation (r) and significance denoted by *p < 0.05; **p < 0.01; ***p < 0.001.