Table 1 Participant characteristics and neuroimaging parameters.
Total | APOE4+ | APOE4- | Statistical test | p | |
|---|---|---|---|---|---|
Demographics | |||||
Number of subjects | 166 (100%) | 63 (37.9%) | 103 (62.1%) | n/a | n/a |
Mean age (sd) | 59.95 (12.85) | 59.47 (11.98) | 60.24 (13.40) | Mann–Whitney | 0.58 |
Sex | F: 109 (65.7%) M: 57 (34.3%) | F: 44 (69.8%) M: 19 (30.2%) | F: 65 (63.1%) M: 38 (36.9%) | Chi square | 0.38 |
Image acquisition | |||||
PET scanner | GE: 71 (42.8%) Siemens: 95 (57.2%) | GE: 25 (39.7) Siemens: 38 (60.3%) | GE: 46 (44.7%) Siemens: 57 (35.3%) | Chi square | 0.53 |
MRI field strength | 1.5T: 121 (72.9%) 3T: 45 (27.1%) | 1.5T: 51 (81.0%) 3T: 12 (19.0%) | 1.5T: 70 (68.0%) 3T: 33 (32.0%) | Chi square | 0.07 |
3T MRI location | NYU : 18 (40%) WCM : 27 (60%) | NYU : 4 (33.3%) WCM : 8 (66.7%) | NYU : 14 (42.4%) WCM : 19 (57.6%) | Chi square | 0.18 |
Mean CT exposure in mAs (sd) | 519.90 (507.81) | 492.08 (501.57) | 536.92 (513.27) | Mann–Whitney | 0.82 |
Mean CT tube current in mA (sd) | 119.16 (47.35) | 125.49 (47.07) | 115.29 (47.32) | Mann–Whitney | 0.11 |
Mean days between MRI and PET (sd) | 105.25 (96.43) | 108.33 (95.80) | 103.37 (97.23) | Mann–Whitney | 0.53 |
Neuroimaging results | |||||
Mean CP calcium volume relative to TICV * 1000 (sd) | 0.21 (0.20) | 0.19 (0.18) | 0.23 (0.21) | Mann–Whitney | 0.43 |
Mean CP overall volume relative to TICV * 1000 (sd) | 1.41 (0.70) | 1.46 (0.88) | 1.38 (0.55) | Mann–Whitney | 0.80 |
Mean Hippocampal volume relative to TICV * 1000 (sd) | 5.67 (0.53) | 5.67 (0.54) | 5.67 (0.53) | T-test | 0.98 |
Mean Cortical PiB SUVr (sd) | 1.21 (0.24) | 1.28 (0.31) | 1.17 (0.18) | Mann–Whitney | 0.22 |
