Table 2 Multiple regression model (R2 = 0.345, R2 adjusted = 0.30, p < .001) predicting hippocampal volume in 165 cognitively normal subjects.

From: Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers

Variable

Unstandardized β

P value

Age

-0.016

< 0.001

Sex

-0.226

0.005

APOE4 genotype

-0.175

0.106

CP calcium volume

-0.174

0.453

CP overall volume

-0.153

0.031

Cortical AB (11 C-PiB SUVr)

-0.194

0.236

CT tube current

0.002

0.097

MR Field strength (3T vs. 1.5T)

0.016

0.823

Days between MRI and PET scanning

0.000

0.650

Interaction between CP calcium and APOE4 genotype

0.001

0.047

  1. Age, sex, CP overall volume, and the interaction between CP calcium volume and APOE4 genotype were significant predictors.
  2. All volumes are normalized to total intracranial volume. Genotype is binarized presence vs. absence of an APOE4 allele.
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