Table 2 Univariate and multivariate Cox proportional hazards analyses for PFS.

Age (years)

< 60

Reference

Reference

≥ 60

0.719 (0.490–1.055)

0.092

0.716 (0.477–1.077)

0.109

Sex

Female

Reference

Male

0.963 (0.566–1.641)

0.891

BMI(kg/m²)

0.973 (0.914–1.036)

0.394

HBV infection

No

Reference

Yes

0.872 (0.598–1.272)

0.477

Types of ICIs

PD-1

Reference

PD-L1

0.625 (0.296–1.321)

0.218

Combined with TKIs

No

Reference

Yes

1.182 (0.812–1.722)

0.383

Tumor maximum diameter (cm)

1.044 (0.999–1.090)

0.054

1.010 (0.961–1.062)

0.691

Tumor number

≤ 3

Reference

> 3

1.353 (0.839–2.181)

0.215

PVTT

No

Reference

Reference

Yes

1.692 (1.143–2.504)

0.009

1.247 (0.773–2.013)

0.365

Lymph node metastasis

No

Reference

Yes

1.234 (0.808–1.884)

0.331

BCLC stage

B

Reference

Reference

C

1.998 (1.357–2.944)

< 0.001

1.694 (1.055–2.719)

0.029

Child-Pugh

A

Reference

B

0.987 (0.537–1.813)

0.965

ECOG PS

0

Reference

≥ 1

1.207 (0.782–1.864)

0.396

NLR

1.088 (1.000–1.183)

0.049

1.091 (0.983–1.211)

0.101

PLR

1.003 (1.001–1.004)

0.005

1.001 (0.999–1.003)

0.385

ALT(U/L)

1.000 (0.999–1.002)

0.648

AST(U/L)

1.001 (0.999–1.003)

0.289

TB (µmol/L)

1.004 (0.989–1.019)

0.624

Albumin (g/L)

0.994 (0.957–1.032)

0.745

PT (s)

0.932 (0.809–1.074)

0.329

Urea nitrogen (mmol/L)

0.968 (0.868–1.079)

0.558

Creatinine (µmol/L)

0.996 (0.985–1.008)

0.512

AFP (ng/mL)

< 400

Reference

≥ 400

1.291 (0.881–1.891)

0.190

Liver ECV group

Lower liver ECV

Reference

Higher liver ECV

1.198 (0.823–1.744)

0.346

Tumor ECV group

Lower tumor ECV

Reference

Reference

Higher tumor ECV

0.502 (0.340–0.742)

< 0.001

0.471 (0.314–0.709)

< 0.001