Table 3 Univariate and multivariate Cox proportional hazards analyses for OS.

Age (years)

< 60

Reference

≥ 60

0.816 (0.519–1.283)

0.378

Sex

Female

Reference

Reference

Male

1.883 (0.899–3.943)

0.093

1.776 (0.820–3.846)

BMI(kg/m²)

0.977 (0.906–1.053)

0.538

HBV infection

No

Reference

Yes

0.832 (0.529–1.309)

0.426

Types of ICIs

PD-1

Reference

PD-L1

0.702 (0.303–1.623)

0.407

Combined with TKIs

No

Reference

Yes

1.001 (0.648–1.546)

0.998

Tumor maximum diameter (cm)

1.085 (1.031–1.142)

0.002

1.027 (0.965–1.093)

Tumor number

≤ 3

Reference

> 3

0.832 (0.478–1.448)

0.516

PVTT

No

Reference

Reference

Yes

1.771 (1.142–2.746)

0.011

1.341 (0.826–2.177)

Lymph node metastasis

No

Reference

Yes

1.203 (0.741–1.952)

0.455

BCLC stage

B

Reference

Reference

C

2.348 (1.458–3.782)

< 0.001

1.809 (1.062–3.083)

Child-Pugh

A

Reference

B

1.563 (0.802–3.044)

0.190

ECOG PS

0

Reference

≥ 1

1.358 (0.766–2.408)

0.295

NLR

1.119 (1.001–1.252)

0.049

1.117 (0.972–1.283)

PLR

1.002 (1.000–1.004)

0.106

ALT(U/L)

1.000 (0.999–1.001)

0.849

AST(U/L)

1.001 (0.999–1.003)

0.299

TB (µmol/L)

1.004 (0.992–1.016)

0.537

Albumin (g/L)

0.980 (0.937–1.025)

0.386

PT (s)

1.059 (0.895–1.254)

0.503

Urea nitrogen (mmol/L)

0.959 (0.841–1.093)

0.529

Creatinine (µmol/L)

0.995 (0.982–1.009)

0.486

AFP (ng/mL)

< 400

Reference

Reference

≥ 400

2.562 (1.632–4.023)

< 0.001

2.064 (1.253–3.399)

Liver ECV group

Lower liver ECV

Reference

Higher liver ECV

1.080 (0.700–1.666)

0.728

Tumor ECV group

Lower tumor ECV

Reference

Reference

Higher tumor ECV

0.382 (0.235–0.621)

< 0.001

0.384 (0.235–0.628)